Autoimmune Disease

Vitiligo autoantibodies can be reactive with several domains of MCHR-1

Published in Blood Weekly, December 11th, 2003

Vitiligo patient autoantibodies to melanin-concentrating hormone receptor react to multiple domains.

"Previously, we reported the identification of autoantibodies against the melanin-concentrating hormone receptor 1 (MCHR-1) in patients with vitiligo. In this study, the B cell epitopes on MCHR-1 that are recognized by these autoantibodies have been identified," scientists writing in the Journal of Investigative Dermatology report.

"Deletion derivatives of MCHR-1-complementary DNA were constructed and then translated in vitro with the concomitant incorporation of [³⁵S]-methionine into the protein products. The...

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Source: Blood Weekly (2003-12-11)

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