Stem-Cell Research
IL-7 receptor expression determines lymphoid cell fate
Published in Blood Weekly, December 11th, 2003
"Signaling through the IL-7 receptor (IL-7R) is necessary for the development of the earliest B- and T-lineage cells," researchers in the United States explained. "IL-7R is first expressed on common lymphoid progenitor cells and is not detected on primitive common myeloid progenitors."
In a recent study, S.J. Purohit and colleagues at the University of Alabama found that "enforced expression of IL-7R on multipotential stem cells does not influence lymphoid versus myeloid cell fate."
"T-cell development was compatible with sustained IL-7R...
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Source: Blood Weekly (2003-12-11)
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