Immunosenescence
CD8+ T cells may have higher levels of internal cytokines as humans age
Published in Blood Weekly, December 18th, 2003
According to published research from Italy, "the ageing process is characterized by a progressive exhaustion of the naive T cell reservoir that is accompanied by a compensatory expansion of effector/cytotoxic CD8+ CD28- T cells. However, the origin and function of this subpopulation is not completely clarified.
"In this study, we examined the intracellular cytokine profile in purified CD8+ T cells obtained from 29 healthy subjects of different ages. Type 1 (IFN-gamma, IL-2, TNF-alpha) and type 2 (IL-4, IL-6, IL-10) cytokines were...
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Source: Blood Weekly (2003-12-18)
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