Lymphocyte Disorders
DOCK2 mediates Rac activation after binding ELMO1; may be a target for therapy
Published in Blood Weekly, December 18th, 2003
"Although the migratory property of lymphocytes is critical for protective immunity, tissue infiltration of lymphocytes sometimes causes harmful immune responses. DOCK2 plays a critical role in lymphocyte migration by regulating actin cytoskeleton through Rac activation, yet the mechanism by which DOCK2 activates Rac remains unknown," researchers in Japan report.
"We found that DOCK2 associates with engulfment and cell motility (ELMO1) through its Src-homology 3 (SH3) domain. When DOCK2 was expressed in T-hybridoma cells lacking...
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Source: Blood Weekly (2003-12-18)
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