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Immunodeficiency

Use of corticosteroids, cyclosporine may stop GVHD in some human SCID patients

Published in Blood Weekly, January 8th, 2004

Use of corticosteroids and cyclosporine may stop GVHD in some human severe combined immunodeficient (SCID) patients.

"An X-linked severe combined immunodeficient (SCID) patient received a nonirradiated erythrocyte transfusion and developed transfusion-associated graft-vs-host disease (TAGVHD), which was controllable with high dose corticosteroids," scientists writing in the journal Bone Marrow Transplantation report.

"Haplo-identical SCT was performed, after a myeloablative conditioning regimen. At day +26, he developed GVHD. Chimerism studies revealed DNA of the erythrocyte transfusion donor (ETD) and recipient only.

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