Published in Blood Weekly, January 8th, 2004
According to published research from Philadelphia, "Gene targeting in embryonic stem (ES) cells followed by preparation of chimeric animals is the most effective method to study the function of a gene during development and differentiation."
P.U. Rani and coauthors working at the Wistar Institute of Anatomy and Biology developed "a cost-effective and convenient method to produce chimeric animals."
"Cryopreserved 8-16 cell mouse embryos were aggregated with ES cells in microwell petridishes (Khillan & Bao, 1997) to obtain blastocysts," they...
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