Antigen-Presenting Cells
APC-expressed indoleamine 2,3-dioxygenase degrades tryptophan; lowers atopy
Published in Blood Weekly, January 22nd, 2004
According to published research from Germany, "there is growing evidence that dendritic cells, the major antigen-presenting cells and T cell activators, have a broad effect on peripheral T cell tolerance and regulation of immunity.
"Very recently, a new feature of regulatory antigen-presenting cells was observed. Certain dendritic cells, monocytes, and macrophages express the enzyme indoleamine 2,3-dioxygenase, and thus because of enhanced degradation of the essential amino acid tryptophan, they modulate T cell activity in specific local tissue...
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Source: Blood Weekly (2004-01-22)
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