Peptides
Vasoactive intestinal peptide blocks chemokine receptors
Published in Blood Weekly, January 22nd, 2004
According to a study from Australia, "chemokines mediate trafficking of leukocytes to sites of inflammation and immune responses through activation of G protein-coupled receptors, which thereby provide appealing targets for novel anti-inflammatory agents.
"VIP is an immunosuppressive neurotransmitter. We show that VIP inhibited the function of chemokine receptors on monocytes and CD4+ T lymphocytes, with impaired chemotaxis and calcium flux in response to the cognate chemokine ligands CXCL12, CCL3, CCL4, and CCL5.
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Source: Blood Weekly (2004-01-22)
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