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Helicobacter Pylori

Pediatric H. pylori Cag A total IgG, IgG subclass, indicate pathology type

Published in Blood Weekly, January 29th, 2004

Total H. pylori Cag A IgG, and IgG subclass, are indicative of pathological differences in children.

"Specific serum IgG subclass antibodies against Helicobacter pylori antigens and recombinant CagA were analyzed in 75 symptomatic children with histologically confirmed H. pylori infection," investigators in England report.

"H. pylori stimulated an IgG1 predominant response, and IgG3 titers showed a positive association with peptic ulcer disease, chronicity of antral inflammation, and density of H. pylori colonization.

"Two methods used for assessing serum IgG CagA antibody status, i.e. Western...

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