Leukemia
High-dose methylprednisolone induces remission in CLL patients
Published in Blood Weekly, January 29th, 2004
"Abnormalities of the p53 gene are known to confer detrimental effects in CLL and are associated with short survival. We have used HDMP to treat 25 patients with advanced refractory CLL of whom 45% had p53 abnormalities shown by one or more methods: flow cytometry, fluorescent in situ hybridization, and direct DNA sequencing," investigators in England report.
"Fifteen were resistant to fludarabine and 16 were non-responders to their most recent therapy. Methylprednisolone had a cytotoxic effect on lymphocytes from 95% of...
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Source: Blood Weekly (2004-01-29)
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