Aplastic Anemia
Th1 polarization underlies hematopoietic dysfunction in AAA patients
Published in Blood Weekly, February 5th, 2004
"Immune dysfunction, which leads to the suppression of hemopoiesis by cytokines that are secreted by activated T lymphocytes, is considered to play a key role in the pathogenesis of acquired aplastic anaemia (AAA)," hematologists in Greece explained.
In a recent study, N.C. Giannakoulas and colleagues at the University Hospital in Patras "investigated the intracytoplasmic expression of type-1 [interferon gamma (IFN-gamma), interleukin (IL)-2] and type-2 (IL-4, IL-10) cytokines in CD4+ and CD8+ T cells before and after in vitro activation in 16 patients with AAA and 17 normal...
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Source: Blood Weekly (2004-02-05)
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