Pulmonary Fibrosis

Bone marrow-derived stem cells active in pulmonary fibrosis

Published in Blood Weekly, February 5th, 2004

Adult stem cells have long been thought to be restricted in their potential to differentiate and regenerate tissues in which they reside.

A study by Sem Phan and colleagues from the University of Michigan, in the Journal of Clinical Investigation, suggests that the collagen overproduction and deposition in the lung causing idiopathic pulmonary fibrosis may develop from cells derived from bone marrow stems cells, rather than parenchymal lung fibroblasts.

The authors induced pulmonary fibrosis in mice that had been altered with bone marrow labeled with a fluorescent green marker protein. In these mice, cells derived from bone marrow-derived stem...

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Source: Blood Weekly (2004-02-05)

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