Published in Blood Weekly, February 5th, 2004
A study by Sem Phan and colleagues from the University of Michigan, in the Journal of Clinical Investigation, suggests that the collagen overproduction and deposition in the lung causing idiopathic pulmonary fibrosis may develop from cells derived from bone marrow stems cells, rather than parenchymal lung fibroblasts.
The authors induced pulmonary fibrosis in mice that had been altered with bone marrow labeled with a fluorescent green marker protein. In these mice, cells derived from bone marrow-derived stem...
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