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Stem-Cell Research

Concepts of stem-cell plasticity reviewed

Published in Blood Weekly, February 5th, 2004

Advances in the understanding of stem-cell plasticity have been reviewed.

"For many years, adult hemopoietic stem cells (HSCs) have been considered 'plastic' in their proliferative and differentiation capacities," scientists in England explained.

"Recently, evidence that supports newer concepts of adult stem cell plasticity has been reported," according to E. Martin-Rendon and colleagues at John Radcliffe Hospital in Oxford. "In particular, stem cells from hemopoietic tissues seem to have 'extraordinary' abilities to generate or switch between hemopoietic and nonhemopoietic lineages, exhibiting an unexpected degree of developmental or differentiation...

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