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Hematology

Effects of gamma radiation on hemoglobin characterized

Published in Blood Weekly, February 12th, 2004

Radiation-induced alterations in the structure of hemoglobin have been characterized.

In a recent study from South Korea, "To elucidate the effect of gamma-irradiation on the molecular properties of hemoglobin, the secondary, and tertiary structures of the protein, and its molecular weight were examined after irradiation at 0.5, 1, 5, and 10 kGy."

"Gamma-irradiation of hemoglobin solutions caused the disruption of the ordered structure of the protein molecules, as well as degradation, cross-linking and aggregation of the polypeptide chains," reported S. Lee and coauthors at Chungnam National University.

"A SDS-PAGE study indicated...

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