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Leukemia

High spontaneous colony growth in CMML predicts short survival

Published in Blood Weekly, February 12th, 2004

Researchers find that high (>100) spontaneous granulocyte/macrophage colony (CFU-GM) formation in chronic myelomonocytic leukemia (CMML) at presentation correlates with increased disease activity and predicts short survival.

"We have originally shown that spontaneous CFU-GM formation in semisolid medium is a characteristic in vitro feature of CMML. However, the clinical significance of spontaneous CFU-GM growth in CMML is unknown so far. CFU-GM growth characteristics were studied in semisolid cultures in the absence of exogenous cytokines using peripheral blood mononuclear cells in 30 patients with CMML at first presentation," researchers in Austria report.

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