Leukemia

Rare combination of genes cause leukemia

Published in Blood Weekly, February 12th, 2004

Two children who developed leukemia after receiving gene therapy for an inherited disease may have been victims of a rare combination of genes that is unlikely to happen in gene therapy for other disorders, a study says.

Researchers at the National Cancer Institute in Frederick, Maryland, discovered that a gene in a virus used to treat the children, who had an inherited immune system disorder, can combine with another gene to cause leukemia in mice.

Utpal P. Dave, MD, first author of a study appearing this week in the journal Science, said that he and his team found that in mice a gene called Lmo2 can combine with another gene, called IL2RG,...

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Source: Blood Weekly (2004-02-12)

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