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Stem-Cell Research

Ultraviolet light facilitates better transduction of bone marrow stem cells

Published in Blood Weekly, February 12th, 2004

Ultraviolet light facilitates better transduction of bone marrow stem cells.

"Deficiencies in skeletal tissue repair and regeneration lead to conditions like osteoarthritis, osteoporosis and degenerative disc disease. While no cure for these conditions is available, the use of human bone marrow derived-mesenchymal stem cells (HuMSCs) has been shown to have potential for cell-based therapy. Furthermore, recombinant adeno-associated viruses (rAAV) could be used together with HuMSCs for in vivo or ex vivo gene therapy," researchers in the United States report.

"Unfortunately, the poor transduction efficiency of these cells remains a significant...

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