Published in Blood Weekly, February 19th, 2004
The identification of vitamin K led to the prevention of countless deaths from bleeding and blood clots, as the vitamin is a cofactor for coagulant enzymes in blood. The antagonist for these enzymes, warfarin, thins blood and is commonly used as an anticoagulant. Warfarin works by inhibiting the vitamin K epoxide reductase multiprotein complex (VKOR), a factor that is needed for blood clotting to occur. Yet the proteins involved in this process have remained elusive.
Now Johannes Oldenburg and colleagues writing in the February 5, 2004,...
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