Stem-Cell Transplantation

Naive T-cell levels in graft correlated with post-SCT naive CD4 cell recovery

Published in Blood Weekly, February 19th, 2004

Recovery of naive CD4 cells after stem-cell transplantation depends on the amount of naive T cells present in the graft.

According to published research from Seattle, "Naive T cells after allogeneic hematopoietic cell transplantation are thought to originate from the engrafted hematopoietic cells."

However, J. Storek and coauthors at the Fred Hutchinson Cancer Research Center identified "a correlation between the number of naive CD4 T cells infused with peripheral blood stem-cell grafts and the absolute number of peripheral naive CD4 T cells on day 30 (r=0.65; p<0.001), day 80 (r=0.63; p<0.001), and day 180 (r=0.66; p<0.001) after...

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Source: Blood Weekly (2004-02-19)

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