Stem-Cell Transplantation

Novel NK cell receptor mediates bone marrow rejection

Published in Blood Weekly, March 4th, 2004

A natural killer (NK) cell receptor has been identified as the mediator of bone marrow allograft rejection.

NK cells "mediate bone marrow allograft rejection," scientists in Japan explained. "However, the molecular mechanisms underlying such a rejection remain elusive."

"In previous analyses, it has been shown that NK cells recognize allogeneic target cells through Ly-49s and CD94/NKG2 heterodimers," noted J. Koike and colleagues at Chiba University. In their study, they discovered a "novel murine NK receptor, NKG2I, belonging to the NKG2 family."

"NKG2I, which was composed of 226 amino acids, showed approximately 40% homology to...

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Source: Blood Weekly (2004-03-04)

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