Hodgkin Disease

Modified cytotoxic T cells ferry interleukin-12 to local tumor sites

Published in Blood Weekly, March 11th, 2004

Modified cytotoxic T cells ferry interleukin-12 to local tumor sites.

According to published research from the United States, "adoptive immunotherapy with Epstein-Barr virus (EBV)-specific cytotoxic T cells (CTL) is effective for the prophylaxis and treatment of EBV-induced lymphoma in hematopoietic stem cell recipients. However, in EBV-positive Hodgkin's disease (HD) the efficacy of adoptively transferred EBV-specific CTL may be limited by tumor-derived immunosuppressive factors, such as T-cell growth factor (TGF) beta, interleukin (IL)-13 and the chemokine TARC. Local delivery of IL-12 to tumor sites by tumor-specific CTL could provide direct antitumor effects and...

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Source: Blood Weekly (2004-03-11)

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