Lymphoma

Study finds direct link between CBP gene and lymphoma

Published in Blood Weekly, March 18th, 2004

Inactivation of the gene CBP in certain immature white blood cells of mice causes lymphoma, a type of cancer also found in humans. The cancer is accompanied by changes in the expression of specific genes associated with development of the disease.

These findings, from researchers at St. Jude Children's Research Hospital and the Mayo Clinic, are published in Cancer Cell.

The key to the success of this work is the so-called "conditional knockout mouse" developed by the joint St. Jude-Mayo team, according to Paul Brindle, PhD, associate member in the St. Jude department of biochemistry. In a conditional knockout mouse, a specific gene is rendered...

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Source: Blood Weekly (2004-03-18)

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