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Renal Transplantation

Monitoring glutathione peroxidase levels may evaluate allograft function

Published in Blood Weekly, March 18th, 2004

After kidney transplantation, monitoring levels of glutathione peroxidase (GSH-Px) may help indicate function of the transplanted kidney, researchers report.

"In animals and humans, the highest level of selenium (Se) occurs in the kidney. This organ is also the major site of the synthesis of the selenoenzyme GSH-Px. Decreased Se levels and GSH-Px activities in blood are common symptoms in the advanced stage of chronic renal failure (CRF)," investigators in Poland report.

"Blood samples for Se levels and GSH-Px activities measurements from patients were collected just before transplantation and 3, 7, 14, 30, and 90 d posttransplant. The Se levels in...

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