Stem-Cell Research
N-linked sialyated sugar receptors support hematopoietic cell-osteoblast adhesion
Published in Blood Weekly, March 18th, 2004
"Hematopoietic progenitor cells proliferate and develop predominantly when they adhere to bone marrow stromal cells such as osteoblasts. Therefore, changes in adhesion may be a common mechanism by which stem cells survive, mature and properly traffic between the bone marrow and the circulation," hematologists in the United States explained.
"To characterize these adhesion molecules," S.M. Crean and colleagues at the University of Michigan "reduced the bone marrow cavity to a simple adhesion assay between KG1a (a CD34+ hematopoietic cell line) and osteosarcoma...
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Source: Blood Weekly (2004-03-18)
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