Hematology

Antisense knockdown in zebrafish models mammalian prothrombin deficiency

Published in Blood Weekly, April 1st, 2004

Antisense knockdown in zebrafish models mammalian prothrombin deficiency.

"Thrombin is a serine protease generated from its zymogen, prothrombin, and plays a central role in the coagulation cascade. It is also important for mammalian development. The zebrafish has now been established as an excellent genetic model for studies on mammalian hemostasis and development," scientists writing in the journal Blood Cells Molecules and Diseases wrote.

"In this report, we used prothrombin-specific antisense morpholinos to knock down the levels of prothrombin to characterize the effects of prothrombin deficiency in the zebrafish embryo. Prothrombin...

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Source: Blood Weekly (2004-04-01)

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