Tissue Engineering

Liposome-mediated gene transfer improves the survival of rodent skin flaps

Published in Blood Weekly, April 15th, 2004

Liposome-mediated gene transfer improves the survival of rodent skin flaps.

"Tissue engineering is an application for gene therapy that is in its infancy. We show that simple liposomal-mediated gene transfer could result in a potentially useful biological effect in the field of wound healing. cDNA encoding the 165 amino acid form of vascular endothelial growth factor (VEGF) complexed to commercially available liposomes was injected into rat skin 1 week before raising a random pattern 3 x 10 cm flap," scientists in the United States report.

"The flap survival was enhanced by 14%, and was accomplished without accessing the arterial inflow of the...

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Source: Blood Weekly (2004-04-15)

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