Published in Blood Weekly, April 15th, 2004
According to a study from Austria, "renal transplant rejection is caused by a lymphocyte rich inflammatory infiltrate that attacks cortical tubules and endothelial cells. Immunosupressive therapy reduces the number of infiltrating cells; however, their exit routes are not known. Here a >50-fold increase of lymphatic vessel density over normal kidneys in grafts with nodular mononuclear infiltrates is demonstrated by immunohistochemistry on human renal transplant biopsies using antibodies to the lymphatic endothelial marker protein podoplanin."
"Nodular infiltrates are...
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