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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . April 22nd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Leukemia Therapy - Specific T-cell replete haploidentical SCT feasible for pediatric ALL

Stem-Cell Transplantation - Recipient CMV status should determine T-cell depletion

Chronic Myelogenous Leukemia Therapy - Cytogenetic CE alone does not reduce post-SCT imatinib efficacy

Paroxysmal Nocturnal Hemoglobinuria - Membranous glomerulopathy reported after allo-SCT in PNH patient

Stem-Cell Transplantation - Fatal post-SCT androgen-related hepatic adenoma described

Stem-Cell Transplantation - Reservation of PBSCs for DLI at harvest improves postrelapse treatment efficacy

Anemia - Anemia among cancer patients can be treated with human erythropoietin

Angiology - Contrast agent concentration in mouse blood used to determine tumor vascularity

Angiology - Early ligation of inferior pancreaticoduodenal artery reduces blood loss

Bladder Cancer - New phase II/III Bexidem trial launched

Blood Bank Management - Company announces updated version of Surround for blood centers

Bone Marrow Transplantation - Biotechnology company announces breakthrough in cord blood stem cell expansion

Brain Tumors - EGF gene may be therapy target and prognostic marker for glioblastoma

Breast Cancer - Androgen receptor polymorphism alters breast cancer risk in hormone therapy

Breast Cancer - Survey reports fall in stem cell transplants for breast cancer

Business & Finance - Medical device company announces sale of rotational thrombectomy technology

Cancer Fraud - Woman says she faked daughter's cancer to keep husband from leaving

Cancer Prevention - West Virginia University cancer program gets top rating

Cancer Risk - Studies fail to find link between cancer and a common fried food chemical

Cholestatic Hepatitis - Liver graft failure occurs despite antiviral prophylaxis

Chronic Lymphocytic Leukemia - Geldanamycin and herbimycin A make leukemia cells sensitive to chemotherapy

Colon Cancer - Researchers discover novel gene profile that may identify colon stem cells

Complementary & Alternative Medicine -  Ginkgo biloba extract stimulates endothelial progenitor cells

Drug Development - Company reports advances in targeting Hypoxia-Inducible Factor

Environmental Health - Prenatal organochlorine exposure linked to low cord blood TNF-alpha levels

Finance - Automated instrument reagent company fails to meet guidance

Finance - Blood-products company reports improved 2003 income

Forecast - Study: CerAxon will corner the neuroprotectant drug market in 2013

Glanzmann Thrombasthenia - Factor VIIa restores aggregation of platelets

HIV/AIDS Diagnosis - Doubly indeterminate HIV Western blot results are negative

Heart Attack - Blood-forming stem cells fail to repair heart muscle

Hematology - Central role of the P2Y12 receptor in platelet activation

Hematology - Cynomolgus macaques model the effects of hemophilia B gene therapy

Hematology - Mediators of cytokine-induced stem-cell survival identified

Hematology - New therapies help patients beat cancer-related anemia

Hematology - Stem cells in the spleen rely on neoangiogenesis for relocalization

Hematology - Thalidomide helps endothelial cells escape doxorubicin-induced apoptosis

Hematology - Thrombin can predict response to tissue factor challenge

Hepatic Cancer - Repeat hepatectomy for recurring metastasis confers survival benefits

Hepatology - Anti-Liv8 depleted bone marrow cells useful for liver regeneration

Hodgkin Lymphoma - FDG-PET imaging should be used in staging early-stage Hodgkin lymphoma

Immunology - ATG and CYA treatment effective for hemophagocytic syndrome

Information Technology - Motion Computing enters partnership to help expedite donated organs, tissue

Leukemia - Aplidin enters phase I trials in pediatric solid tumors, leukemias

Leukemia - Researchers discover green tea component helps kill cancer cells

Leukemia - Researchers testing compounds that may stop replication of T-cell virus

Leukemia - U.S. Senator encourages bone marrow donation

Leukemia Diagnostics - Standardized protocols for RQ-PCR residual disease analysis developed

Liver Disease - Phase I pharmacokinetic trial of orally dosed histamine completed

Lymphoma - NHL-associated systemic AL amyloidosis characterized

Lymphoma - Ocular muscle paresis sign of toxic neuropathy associated with vincristine use

Lymphoma - Retroperitoneal lymphoma presenting as pancreatic tumor responds to chemotherapy

Medical Equipment - Blood volume analyzer purchased by NYU Medical Center Tisch Hospital

Mergers & Acquisitions - Genesis completes $2M bridge financing and definitive merger agreement

Metastasis - Powerful stem cells harnessed to search for cancer spread

Multiple Myeloma - SGN-40 phase I clinical trial initiated in multiple myeloma

Nephrology - Gene therapy shows promise for treating renal diseases

Neurodegenerative Diseases - Alliance to develop non-embryonic stem cell therapies

Non-Hodgkin Lymphoma - Monkey virus may hold clue for development of common blood cancer

Oncogenesis - CBP loss mediates lymphomagenesis in synergy with reduction of p27(Kip1)

Organ Transplant - Clarian Health organ transplants rank fourth in nation

Patents - Global patents for Fosrenol sold to Shire Pharmaceuticals

Sepsis - Antioxidants may increase sepsis survival

Sepsis - Company receives preclinical report on MDI-P

Sepsis - Endotoxin Activity Assay sepsis marker included in distribution agreement

Sepsis - Notice Of Allowance issues for sepsis and renal failure assay technology

Sickle Cell Disease - New therapeutic approach for blood disorder described

Sickle Cell Disease - Patients living longer, dying less from genetic blood disease

Stem-Cell Biology - Research may give rise to spine injury treatment

Stem-Cell Research - Autophagy gene beclin 1 is haploinsufficient tumor suppressor

Stem-Cell Research - Circulating CD14+ monocytes contain progenitors with mesenchymal cell differentiation

Stem-Cell Research - Influence of p38 MAP kinase isoforms on erythroid differentiation determined

Stem-Cell Research - Marrow stromal cells selected by serum deprivation express embryonic genes

Stem-Cell Research - Mesenchymal stem cells may be useful for hard tissue regeneration

Stem-Cell Research - Morphological and ultrastructural neurosphere features characterized

Stem-Cell Research - Pediatric brain tumors contain malignant stem cells

Stem-Cell Research - Wnt proteins promote neural stem-cell differentiation in vitro

Stem-Cell Research - Wnt signals control immature thymocyte proliferation, cell adhesion

Stem-Cell Transplantation - Benefits and drawbacks of umbilical cord blood transplantation reviewed

Stem-Cell Transplantation - MURR enters into holmium-166 agreement

Stem-Cell Transplantation - Risk factors for posttransplant TB in South Korea identified

Stroke - Consider tumor embolization in differential diagnosis of stroke after lung cancer surgery

Transplant Medicine - Babies can get hearts with wrong blood

Transplant Medicine - Central pontine myelinolysis is a complication of liver transplantation

Transplant Medicine - Cotransplanted third-party cells improve double cord blood transplantation

Transplant Medicine - Cytokine genes are key to hepatitis C virus recurrence in liver graft patients

Transplant Medicine - Researchers describe feasible alternative to bone-marrow donation

Tuberculosis Diagnostics - PRIMAGRAM assay useful with skin test for TB diagnosis in macaques

Tumor Suppression - SDHD is the first known tumor suppressor gene encoding a mitochondrial protein

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