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Leukemia Diagnostics

Standardized protocols for RQ-PCR residual disease analysis developed

Published in Blood Weekly, April 22nd, 2004

Standardized protocols have been developed for the RQ-PCR analysis of residual leukemic disease.

"Detection of minimal residual disease (MRD) has proven to provide independent prognostic information for treatment stratification in several types of leukemias such as childhood acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and acute promyelocytic leukemia," explained oncologists in France, who examined "the accurate quantitative measurement of fusion gene (FG) transcripts as can be applied in 35-45% of ALL and acute myeloid leukemia, and in more than 90% of CML."

"A total of 26 European university laboratories from 10 countries have...

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