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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . April 29th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Hematological Cancer Therapy - Risedronate prevents and reverses bone loss in stem-cell graft recipients

Immunology - Activity of cord blood T cells characterized

Leukemia Therapy - Post-HSCT dendritic cell recovery kinetics determined

Stem-Cell Research - CD41 expression defines hematopoiesis onset in the murine embryo

Anti-Infectives - Ciprofloxacin can prevent infection in pediatric cancer patients

Bacteriology -  Helicobacter pylori CagA protein variation may increase risk of gastric cancer

Biomaterials - PHBHHx has good affinity with bone marrow stromal cells

Blood Testing - Anti-Mullerian hormone levels used to investigate prenatal abnormal genitalia

Blood Transfusions - Twenty trial sites recruited for acute transfusion study

Cancer Detection - Sentinel lymph node biopsy effective for pathologic staging of solid neoplasms

Cancer Metastasis - Mounting evidence that Ezrin promotes tumor metastasis

Cancer Therapy - Early, high-dose chemotherapy with HPCS effective for poor prognosis GCT

Cancer Therapy - INO-1001, novel inhibitor of PARP, enhances radiation sensitivity

Chemotherapy - Cumulative etoposide doses prognostic factor for transplant-related mortality

Complementary & Alternative Medicine - Company secures patents for gut-based uremia therapy products

DNA Repair - Grape seed procyanidin extract prevents DNA lesions in hepatocytes in vitro

Diagnostics - Retrograde ureteropyelography demonstrates fibroepithelioma of left ureter

Diagnostics - SPE-LC-ESI MS/MS method rapid and sensitive detection of CAP in seafood

Diagnostics - Thorough training necessary for endorectal ultrasound-guided biopsy

Gene Expression - CD43 involved in nuclear signaling and cell proliferation via beta-catenin

Gene Expression - Ku86 levels correlate with magnitude of radiation-induced lymphocyte DNA breaks

Gene Expression - TRAF3 required for signaling by LMP1 but not CD40 in B cells

Genomics - Company to provide Merck with genetic rat models

Genomics - Distinct mechanisms lead to HPRT gene mutations in leukemic cells

Gift Awards - Eli Lilly gives $6 million to group that sued a year ago

HIV/AIDS - Role of monocytes in latent HIV infection reviewed

HIV/AIDS Cancer - Serum samples preferable for PCR-based Kaposi sarcoma diagnosis

HIV/AIDS Therapy - Fludarabine-loaded RBCs can clear HIV macrophage reservoir

Hematology - Effect of gamma radiation on hemoglobin clarified

Hematology - Munc13-4 regulates dense core granule secretion in platelets

Hemochromatosis - New mutation in hepcidin linked to juvenile hemochromatosis

Hemolytic Anemia - Compound mutations cause hemolytic anemia and severe rhabdomyolysis

Hepatitis C Epidemiology - Prevalence of hepatitis C high among homeless of Oxford, England

Imaging - Novel MRI technique provides clear images of blood flow

Immunology - Whole blood samples may produce low FACS antigen-specific T-cell counts

Irradiated Blood - Company announces first North American sales of Raycell blood irradiator

Legal Issues - Health insurer to pay for disputed bone marrow transplant

Leukemia - Company completes NDA for clofarabine

Leukemia - Hematopoietic reserve evaluated in B-CLL patients

Leukemia - Molecular analyses of leukemia patients suggest strategies for better treatments

Leukemia - Phase II trial of BCX-1777 initiated in T cell leukemia

Leukemia - Study expands on effectiveness of AP23464, in Gleevec-resistant leukemia cells

Malaria Enzymology - Novel E. coli expression system provides functional plasmodial fp2

Molecular Diagnostics - PGP9.5 mRNA contributes to medullary thyroid carcinoma molecular-based diagnosis

Molecular Virology - p185/Cu17-binding-defective Tag mutants unable to transform fibroblasts

Multiple Myeloma - Phase III pivotal trial for STR begins

Mycology - Pulmonary cryptococcosis presents as solitary focal ground-glass opacity on HRCT

Myelodysplasia - New test shows promise for diagnosing myelodysplasia

Myelodysplastic Syndromes - Results reported from Dacogen phase III study in myelodysplastic syndromes

Myeloid Leukemia - Cloretazine studied for acute myeloid leukemia or myelodysplastic syndromes

Oncogenesis - CBP loss causes T cell lymphomagenesis in synergy with p27(Kip1) insufficiency

Oral Cancer - Overexpression of COX-2 is associated with radioresistance in oral SSC

Pancreatitis - Pancreatic involvement in systemic sarcoidosis with high serum amylase/lipase

Parvovirus B19 - Persistent parvovirus B19 infection without chronic anemia reported

Personnel - Pediatric-focused pharma company promotes Martin P. Manco

Personnel - University of Washington names Pittsburgh doctor as new transplant chief

Radiocontrast Nephropathy - Company announces postmarket study of its Benephit Infusion System

Skeletal Disease - Skelite orthopedic products win CE mark

Stem Cell Biology - Lab finds way to grow large number of neurons from stem cells

Stem-Cell Research - IL-21 induces rapid maturation of natural killer cell precursors

Stem-Cell Research - M1 muscarinic receptors expressed by neuronal progenitors

Stem-Cell Research - MEK-1/ERK signals have differential effects on erythroid progenitor self-renewal

Stem-Cell Research - Matrigel effective for neuronal differentiation of MSCs in culture

Stem-Cell Research - Murine and human ES cell hematopoiesis models reviewed

Stem-Cell Research - NF-kappaB/Rel-mediated apoptosis regulation reviewed

Stem-Cell Research - Neurogenesin-1 induces neurogenesis in adult hippocampus

Stem-Cell Research - Retinoic acid suppresses LIF signaling in murine embryonic stem cells

Stem-Cell Transplantation - Novel regimens allow mixed chimerism with T-cell depletion in mice

Stroke - Antiplatelet pill key to preventing surgery complications

Surgical Technique - EUS-FNA sensitive and specific alternative to surgical procedures

Tissue Culture - Generation of 3-D pannus-like tissues in vitro show differentiation in arthritis

Transfusion Medicine -  C. perfringens alphaNAG converts type A2 blood cells to type O

Transplant Medicine - Daughter's liver donation gives mom new life

Transplant Medicine - Liver transplant recipient needs another procedure

Transplantation Medicine - Blood test useful for monitoring immunosuppressant interactions

Tumor Suppressor Gene - Phagocytosis of necrotic cells does not induce inflammatory cytokine production

Von Willebrand Disease - PltGPs do not affect clinical expression of von Willebrand disease type I

Wound Care - Utility of fibrin glues for wound repair reviewed

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