Cancer Therapy

INO-1001, novel inhibitor of PARP, enhances radiation sensitivity

Published in Blood Weekly, April 29th, 2004

INO-1001, a novel inhibitor of PARP, enhances radiation sensitivity.

"Inhibition of poly(ADP-ribose) polymerase (PARP) by a novel, potent inhibitor, INO-1001, was examined in two rodent and one human fibroblast cell lines, after single and fractionated radiation treatments. Since PARP plays a role in the early events following DNA damage and influences the effectiveness of DNA repair, its inhibition has been proposed to constitute a drug target for the development of novel radiosensitizers," wrote scientists at the M.D. Anderson Cancer Center..

INO-1001 was shown to effectively inhibit "PARP activity at noncytotoxic concentrations. Combination...

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Source: Blood Weekly (2004-04-29)

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