Stem-Cell Research

NF-kappaB/Rel-mediated apoptosis regulation reviewed

Published in Blood Weekly, April 29th, 2004

NF-kappa B/Rel-mediated regulation of apoptosis in healthy and malignant hematopoietic cells has been reviewed.

"The activity of NF-kappaB/Rel transcription factors can downmodulate apoptosis in normal and neoplastic cells of the hematologic and other compartments, contributing in maintaining neoplastic clone survival and impairing response to therapy," scientists in Italy explained. "Alterations in nfkappab or ikappaB genes are documented in some hematologic neoplasias, while in others dysfunction in NF-kappaB/Rel-activating signaling pathways can be recognized.

"The prosurvival properties of NF-kappaB/Rel appear to rely on the induced...

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Source: Blood Weekly (2004-04-29)

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