Stem-Cell Research

Retinoic acid suppresses LIF signaling in murine embryonic stem cells

Published in Blood Weekly, April 29th, 2004

Retinoic acid (RA) suppresses LIF signaling in murine embryonic cells.

Treatment with RA "induces the differentiation of murine embryonic stem (ES) cells to cell types resembling those found in the early embryo," scientists in New York explained. "When cultured in the presence of leukemia inhibitory factor (LIF), ES cells are maintained in an undifferentiated (self-renewing) state. Addition of RA to the culture media overrides the self-renewing effects of LIF to induce ES cell differentiation.

"Therefore," A.P. Tighe and colleagues at Cornell University "hypothesized that RA-induced differentiation of ES cells may be accomplished by antagonism of...

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Source: Blood Weekly (2004-04-29)

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