Adverse Drug Effects
Long-term studies show transduced stem cells do not cause leukemia
Published in Blood Weekly, May 20th, 2004
"There has been significant progress toward clinically relevant levels of retroviral gene transfer into hematopoietic stem cells (HSC), and the therapeutic potential of HSC-based gene transfer has been convincingly demonstrated in children with severe combined immunodeficiency syndrome (SCID). However, the subsequent development of leukemia in two children with X-linked SCID who were apparently cured after transplantation of retrovirally corrected CD34+ cells has raised concerns regarding the safety of gene therapy approaches utilizing integrating vectors," scientists writing in the journal Molecular...
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Source: Blood Weekly (2004-05-20)
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