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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . May 27th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Hematology - New red cell processing techniques extend blood bank shelf life

Proteomics - NO66 has role in ribosome biogenesis and replication of heterochromatic regions

Stem Cell Research - Cord blood cell-transplanted mice develop functional human immune system

Stem-Cell Research - Coculture system successfully induces embryonic stem cell differentiation

Stem-Cell Research - Growth dynamic of stem cells major determinant of tumor susceptibility

Acute Myeloid Leukemia - A combined regimen is active against refractory acute myelogenous leukemia

Alcoholism - Liver transplantation is the sole option for many with alcoholic liver disease

Allergy & Immunology - Cancers with the most intense IGF-I receptor expression may be more aggressive

Allergy & Immunology - Findings support importance of gammadelta T cells in allergy development

Allergy & Immunology - Helminth infection has a role in allergen-induced airway inflammation

Anemia - Blood disorder associated with disability, poorer physical performance

Anemia - Factor identified for low iron in patients with infections, inflammatory diseases

Anemia - Iron-deficient infants score worse on cognitive, motor tests as teens

Blood Banking - Galileo cleared by U.S. Food and Drug Administration for use in U.S.

Blood Coagulation - Study reports in vitro evidence of gender-related heparin resistance

Brain Cancer - Bone marrow-derived stem cells used for potential treatment of gliomas

Breastfeeding - Mother's milk may prevent sepsis in extremely low-birth-weight infants

Chronic Hepatitis C - HCV genetic variability in liver transplant recipients differs with progression

Chronic Kidney Disease - Guidelines recommend antihypertensive therapy to cut CVD risk for CKD patients

Clinical Trials - Researchers develop optimal estimator for clinical trials

Collaborations - Ortec to collaborate to facilitate stem-cell therapy development

DNA Research - High frequency of intrachromosomal homologous recombination in mammalian cells

Diagnostics - Imaging techniques increase identification of MM cytogenetic abnormalities

Drug Development - Organic copper complexes are a new class of tumor-selective inhibitors

Endocrinology - Healthy aging associated with psychoneuroendocrine alterations

Endocrinology - Sex steroid receptors in human skin differentially localized

Endocrinology - T3 exposure causes myocardium hypertrophy and increased SR Ca2+ ATPase activity

Endocrinology - p53 gene abnormality restricted to poorly differentiated endocrine carcinomas

Environmental Health - Researcher finishes collecting samples for leukemia investigation

Estrogen - Estrogen-related receptor beta involved in proliferation of gonadal germ cells

Finance - Healthcare technology company completes $580,000 private placement

Finance - San Diego, California-based pharma secures series A financing

Genomics - 100 nucleotides necessary to promote cap-independent STNV-1 RNA translation

Genomics - Amplification/overerepresentation of 12q13-15 region genes involve LMS and RMS

Genomics - ETO interaction domains within N-CoR first step in AML molecular therapy design

Genomics - Transcription factors and coactivators associated with StAR proximal promoter

Hematology - Angiogenesis inhibition is a key aspect of leukemia therapy

Hematology - CD7 and CD56 antigens associated with low remission rate in acute leukemia

Immune System - Postweaning multisystemic wasting syndrome confers diminished immune response

Immunology - ATF3 expression may normally be induced by loss of target-derived NGF and GDNF

Immunology - Angiotensin II major target to control pathological inflammation in colon

Immunology - CTLA4 gene involved in Grave disease and autoimmune thyroid disease risk

Immunology - Correlation between disease severity and anti-MOG Ab titer in progressive MS

Immunology - Design basis elucidated for orally active agents for celiac disease

Immunology - Energy metabolism low during wound healing in immunocompromised and aged rats

Immunology - Fourth immunoglobulin light chain isotype characterized in the common carp

Immunology - Glutaminase present on the surface of human polymorphonuclear neutrophils

Immunology - Human anti-GM IgM antibodies detected in children after 1 month of age

Immunology - Human serum inactivates non-glycosylated G-CSF by a protease dependent mechanism

Immunology - Immature dendritic cells from spleen progenitors show limited T cell stimulation

Immunology - PCR-based genotyping method can elucidate ecological impact of Mhc diversity

Immunology - Paroxetine inhibits acute effects of MDMA on immune system in humans

Immunology - Xenon and isoflurane opposite effects on LPS-induced TNF-alpha/IL-6 production

Inflammation - Exercise-induced adaptive responses reduce age-associated inflammation

Leukemia - Chromosome losses may mean poor survival in childhood leukemia

Leukemia - FDA approves Cladribine injection for hairy cell leukemia

Leukemia - FDA grants approval for fludarabine phosphate injection

Leukemia - Frameshift mutations at the Dok1 gene mark chronic lymphocytic leukemia

Liver Transplantation - Viral response endures in transplant recipients treated for recurrent HCV

Multiple Myeloma - Ability of myeloma cells to secrete MIP-1 linked to lytic bone lesions

Mutagenesis - Hepatitis C virus uses hit-and-run mechanisms to boost cancer formation

Myocardial Infarction - Hopes dampened for transplanting bone marrow stem cells in heart attacks

Neuroendocrinology - Neurotrophins involved in biology of the gastrointestinal neuroendocrine system

Neurology - Extraretinal photoreceptors found in the teleost Phoxinus phoxinus

Neurology - Peroxisomes in glial cells may control development of neurons

Neurophysiology - Neurological stress alters expression of glutamate transporter EAAT2b

Olfactory - Scent-marking displays provide signals of health and infection

Organ Donation - Illinois governor gets bill to let people with HIV donate organs

Organ Transplant - Artificial heart implanted in patient at Jewish Hospital in Louisville

Parkinson Disease - Dental pulp cells may hold key to treatment of Parkinson

Preimplantation Genetic Diagnosis - Testing can determine if embryo can be potential stem-cell donor for sibling

Product Licensing - Geron grants license for nuclear transfer technology

Sickle Cell Disease - Genetic blood disease produces silent strokes

Sickle Cell Disease - Twice daily administration of Niprisan shows promise for sickle cell disease

Signalling Pathways - Multiple signaling pathways involved in hypertrophic effect of hsp56

Stem Cell Research - Interleukin-10 gene therapy engenders tolerance to heart transplantation

Stem-Cell Research - Baton Rouge center reports stem-cell breakthrough

Stem-Cell Research - Bone repair/replacement possible using tissue engineering techniques

Stem-Cell Research - Cell fusion, not transdifferentiation, causes BM-derived cell regeneration

Stem-Cell Research - Cytokines IL-7, SCF and Flk-2L essential for lymphocyte development

Stem-Cell Research - Elucidating molecular codes for stem cell states crucial for future therapy

Stem-Cell Research - Louisiana House panel debates an end to cloning

Stem-Cell Research - Mesenchymal stem cells established in 3-D hyaluronan-based scaffolds

Stem-Cell Research - Natural killer cell lineage probably CD4+CD8+ thymocytes

Stem-Cell Research - New biodegradable composite scaffold for guided bone regeneration noncytotoxic

Stem-Cell Research - Smad5 negative regulator of embryonic hematopoiesis

Stem-Cell Research - Sox21 is a repressor of neuronal differentiation in developing nervous system

Stem-Cell Research - Study variations debate mesenchymal stem cell presence in peripheral blood

Stem-Cell Research - mRif1 highly expressed in germ cells and embryo-derived pluripotent stem cells

Survival & Mortality - High predischarged cTnT in acute anterior MI increase short-term mortality risk

Thrombophilia - Enoxaparin prevents stillbirth in pregnant women with clotting disorder

Transfusion Medicine - Allogeneic blood transfusions stimulate angiogenesis in infused patients

Transplant Medicine - Adenovirus disease in transplant patients worsens with immunosuppressive therapy

Transplant Medicine - Campath immunosuppression causes earlier development of LP infiltrates

Transplant Medicine - Hyperhomocysteinemia common in pediatric renal transplant recipients

Transplant Medicine - New liver allocation plans have improved transplant rates

Transplant Medicine - No evidence for EBV infection as risk factor for pediatric renal transplant PTLD

Transplant Medicine - Preoperative scores predict survival after liver retransplantation

Transplant Medicine - Short sirolimus half-life in pediatric renal transplants without calcineurin

Transplant Medicine - Transplant rejection averted by simple light exposure in Stanford animal study

Viral Genomics and Genetics - Human T-cell leukemia virus type-1 integration correlates with leukemogenesis

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