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Hematology

Angiogenesis inhibition is a key aspect of leukemia therapy

Published in Blood Weekly, May 27th, 2004

Angiogenesis inhibition is a key aspect of leukemia therapy.

According to a study from Italy, "the bone marrow microenvironment plays a crucial role in leukemogenesis. Recent studies suggest that its vascularity changes significantly during this process and that angiogenic factors are of major importance in leukemia. This review summarizes the literature concerning the relationship between angiogenesis and the progression of acute and chronic lymphocytic leukemia.

"It is becoming increasingly evident that agents which interfere with angiogenesis also block tumor progression and antiangiogenic management has become a prominent aspect of preclinical...

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