Immunology

ATF3 expression may normally be induced by loss of target-derived NGF and GDNF

Published in Blood Weekly, May 27th, 2004

Activating transcription factor-3 expression may normally be induced by the loss of target-derived nerve growth factor and glial cell line-derived neurotrophic factor.

"Activating transcription factor-3 (ATF3) is a member of the ATF/CREB transcription factor superfamily and is induced in dorsal root ganglion (DRG) cells after nerve injury. In order to study the regulation of ATF3, we have examined the effect of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) on ATF3 expression," wrote scientists in England.

"In untreated rats, sciatic nerve transection induced ATF3 immunoreactivity in 82% of L4 DRG cells at 14 days...

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Source: Blood Weekly (2004-05-27)

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