Published in Blood Weekly, May 27th, 2004
"Ectopic activation of the Writ signaling pathway is highly oncogenic for many human tissues." Data showed "that ectopic Writ signaling increases the effective stem cell activity in mouse mammary glands in vivo. Furthermore, Writ effectors induce the accumulation of mouse mammary epithelial progenitors (assayed by Hoechst dye exclusion, a surrogate stem cell marker, side population cells) both in vivo and in vitro," wrote investigators at the University of Wisconsin.
"The longevity of stem cells makes them good candidate tumor precursors, and we propose that Wnt-induced...
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