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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . June 3rd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - Prestorage plasma filtration activates the complement cascade

Retrovirus - Human T-lymphotropic virus type 1 can spread directly between lymphocytes

Stem-Cell Research - Blastocyst-derived cell is source of neural derivates for differentiation study

Stem-Cell Research - Direct cell contact influences fate of bone marrow mesenchymal stem cells

Stem-Cell Research - Human neural progenitor cells possible source for treatment of Parkinson disease

Addiction Medicine - Family history predicts alcohol relapse after liver transplantation

Allergy - Allergic fungal rhinosinusitis occurs in 6% of chronic rhinosinusitis

Allergy - Unknown mechanism of action involved in expression of cytokines in mast cells

Alzheimer Disease - APP contributes to inflammatory condition in Alzheimer disease

Angiology - Enhanced iNOS expression associated with progression of CAL in Kawasaki disease

Angiology - Patients with moderate thrombocytopenia do not require treatment

Apoptosis - Fas-mediated apoptosis enhanced in ageing human keratinocytes

Blood Cancer - $14.9M in grants to fund research for blood cancer treatments

Blood Safety - Blood donors in Lagos, Nigeria, misinformed regarding safety of donating blood

Bloodstream Infections - Dalbavancin superior to vancomycin for bloodstream infections, data shows

Bone Defects - Pennington scientists turn human fat cells into bone

Bone Marrow Transplant - Scientists show adult blood stem cells can transform into brain cells in people

Breast Cancer - Minimal residual breast cancer detected using CK19 and EGF-R primers in RT-PCR

Business Update - Biologics company announces closing of reorganization and cash infusion

Cell Therapy - TALL-104 cells injure glioma cells by apoptotic and necrotic pathways

Chemotherapy - HDCT improves cure rate of young children with medulloblastoma and stPNET tumors

Chronic Hepatitis B - Hepatitis B virus genotypes have no bearing on outcomes after liver transplants

Chronic Hepatitis C - Good management of hepatitis C requires thorough pretreatment evaluation

Citrobacter Rodentium - Novel C. rodentium type III secreted proteins reduce colon hyperplasia

Cloning - Company provides two NIH agencies with open access to cloning technologies

Cryptococcosis - Mononuclear phagocytes are a vehicle for cryptococcal dissemination

Cytokines - Cytokines IL-8 and IL-10 are prognostic factors in burn sepsis

Cytomegalovirus - Myeloid progenitor genes affected by latent CMV infection identified

Dengue Virus - No new cases detected following dengue 3 epidemic in Havana

Diabetes Complications - "Good guy" blood cells are now suspects in heart disease, diabetes

Diabetes Risk Factor - Hepatitis C virus may be a diabetes trigger in liver transplant recipients

Diagnostic Imaging - Cirrhotic nodules sometimes resemble liver cancer on computed tomography

Diagnostics - Tc-99m-GSA scintigraphy complements liver function analysis before hepatectomy

Dialysis - Novel hemoperfusion method attenuates dialysis-related amyloidosis

Endocrinology - Somatostatin receptor subtype 2 represents cell differentiation marker in tumors

Endocrinology - Vasopressin release reduced in ovariectomy restored by oestradiol replacement

Enzymology - Trypsin IV is a novel agonist of protease-activated receptors 2 and 4

Finance - Biotechnology company reports first quarter 2004 financial results

Finance - Blood-processing company reports increased revenues

Gastroenterology - Enteral absorption of CsA good in very small children following liver transplant

Genetics - Pathogenetic role for BCL6 translocation in B-cell non-Hodgkin lymphoma

Genomics - Beta-catenin regulates the gene of unique novel matrix metalloproteinase-26

Genomics & Genetics -  Caenorhabditis elegans eukaryotic IFF-1 required for germ cell proliferation

Graft-Versus-Host Disease - Ultraviolet light exposure prevents graft-versus-host disease in animal study

Graft-versus-Host Disease - Nonmyeloablative regimens reduce incidence of GVHD better than myeloblative

HIV/AIDS - HIV-1 viral load increase confers virus escape risk via recombination diversity

HIV/AIDS Research - IKK2 inhibitor alleviates kidney and wasting diseases in murine AIDS model

HIV/AIDS Research - RH116 differentially regulates cell growth, death and HIV-1 replication

HIV/AIDS Treatment - HLA-B*5701 and Hsp70-Hom M493T alleles necessary for abacavir hypersensitivity

Hematology - Some para-sulfonato-calix-[n]-arenes possess hemolytic properties

Hemolytic Anemia - Rituximab rapidly effective for patients with cold and warm autoantibodies

Hepatitis C Epidemiology - Risk factors for hepatitis C in Alaska natives reported

Hepatitis C Virus - HCV compartmentalization in circulating B cells and monocytes is common

Hepatitis C Virus - High viral loads and diverse viremia characterize pediatric HCV infection

Hepatitis C Virus - MMF does not decrease viral load in chronic HCV liver transplant recipients

Immunology - CCR5Delta32 risk factor for biliary lesions following liver transplantation

Immunology - Changing IVIG preparations increases risk of adverse effects

Immunology - Estrogen receptor beta localized to mitochondria

Immunology - Fas, Fas ligand, Bcl-2 and TGF beta 2 not associated with glioma prognosis

Immunology - Immunoreactivity higher to non-pathogenic strains of Acanthamoeba

Immunology - Isoenzyme inhibitors have therapeutic potential to target inflammatory cells

Immunology - Liver transplant recipients benefit from rabbit antithymocyte therapy

Immunology - Modification of BCR tonic signals activates receptor editing in immature B cells

Immunology - Novel transcriptional regulator AhR contributes to suppression of IgM production

Immunology - Scientist addresses theory on mind-body connection to controlling immune system

Immunology - Tyrosine-mediated inhibitory signals contribute to CTLA-4 function

Immunology - UEC response to bacteria regulate immune protection in female reproductive tract

Infectious Disease - Factors involved in vertical T. cruzi transmission identified

Leukemia - Bone marrow VEGF levels parallel the phases of chronic myeloid leukemia

Liver Disease - Hepatocyte growth factor used to prevent CD95-mediated hepatocellular damage

Liver Transplantation - Centrilobular alterations signal higher rejection odds after liver allografts

Lymphoma - Blastic NK-cell-like lymphoma with TCR gene rearrangement reported

Malaria Vaccine -  Plasmodium falciparum peptides bind to human hepatocytes

Medical Devices - Transesophageal Doppler predicts cardiac output during hemodynamic changes

Mergers and Acquisitions - Cell therapy companies sign letter of intent to merge

Microbiology - Nurse cell cytoplasm differs between two Trichinella species

Multiple Myeloma - Altered bone microenvironment selects for highly aggressive myeloma cells.

Myelodysplastic Syndrome - Allogeneic bone marrow transplantation can cure myelodysplastic syndrome

Non-Hodgkin Lymphoma - Interim results reported on Theralux trial

Nutrition - Eliminating iodine deficiencies: goal for 2005

Obesity - PPARs targets for obesity and related disorders

Obesity - Weight loss is critical to effective management of obesity hypertension

Obstetrics - In utero exposure to maternal smoking induces nicotine withdrawal in neonates

Paroxysmal Nocturnal Hemoglobinuria - Results of trial evaluating use of eculizumab presented at hematology meeting

Patents - CryoSeal FS System receives Japanese patent

Pathology - The continuum of hepatitis C-related fibrosis grows with alcohol intake

Personnel - Instrument-reagent systems provider promotes De Chirico to CEO

Pharmacology - Pro-nucleotide inhibitors of adenylyl cyclases potentially therapeutic

Plastic Surgery - Bone marrow cells improve flap survival after ischemia-reperfusion injury

Prions - Prnp transfection suppress CVB3 replication in prion protein gene-deficient cell

Proteomics - BmpA plays an essential role in Borrelia burgdorferi biology

Proteomics - Tumor necrosis factor and monocyte chemoattractant protein aid myeloma travel

Reproduction - Age-related changes found in seminiferous tubules of hamsters

Retrovirus - B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis

Retrovirus - Close association between immune response and SIV encephalitis in macaques

Stem-Cell Research - Direct Dlx homeodomain target identified in developing forebrain and retina

Stem-Cell Research - Embryonic stem cell gene array expression profiling leads to functional analysis

Stem-Cell Research - FGF2 signaling determines beta-catenin effect on neural stem cell proliferation

Stem-Cell Research - GVHD associated with lower relapse after ALL hematopoietic stem cell transplant

Stem-Cell Research - Hematopoietic stem cells adopt mature hematopoietic fates in ischemic myocardium

Stem-Cell Research - Innovative tissue engineering structure powerful means to study cell response

Stem-Cell Research - MERG1A may play a role in early mouse embryogenic development

Stem-Cell Research - Mesenchymal stem cells make cardiac connexins and form functional gap junctions

Stem-Cell Research - Mesothelial cell progenitors able to switch between different cell phenotypes

Stem-Cell Research - Neointestinal cysts found after intestinal epithelium organoid implantation

Stem-Cell Research - Tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar

Toxoplasma - Multimerization of T. gondii MIC2 protein required for binding heparin/cells

Transplant Medicine - Cancer recurrence after liver transplantation shortens survival

Transplant Medicine - Living and cadaveric livers yield similar outcomes in hepatitis C patients

Transplant Medicine - MELD has improved survival odds for liver cancer patients awaiting transplants

Virology - BK virus load correlates with clinical course of infection in renal transplants

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