Published in Blood Weekly, June 3rd, 2004
"The susceptibility of prion protein gene (Prnp)-null cells to coxsackievirus B3 (CVB3) was investigated. Primary cultures of murine Prnp(-/-) brain cells were more sensitive to CVBs than corresponding cells from wild-type mice. The viral susceptibility of a Prnp-null cell line (HpL3-4) derived from the murine hippocampus was compared with that of two established cell lines (HeLa and HEp-2) that are widely employed for CVB3 studies," wrote scientists in Japan.
"After infection with CVB3, HpL3-4 cells showed a very rapid and complete cytopathic effect (CPE). CPE...
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