Retrovirus
B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis
Published in Blood Weekly, June 3rd, 2004
"Apoptosis in lymph node (LN) T cells of feline immunodeficiency virus (FIV)-infected cats is associated with cells co-expressing B7.1 and B7.2 co-stimulatory molecules, and their ligand CTLA4. To study the possibility of B7.1/B7.2-CTLA4 mediated T-T interactions and the predicted induction of T cell apoptosis in vitro, co-stimulatory molecules were up-regulated on CD4+ and CD8+ T cells by mitogen stimulation," wrote scientists at North Carolina State University.
"B7.1 expression on in vitro stimulated CD4+ and...
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Source: Blood Weekly (2004-06-03)
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