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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . June 10th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Cell Proliferation - Hepatocyte proliferation enhanced by immobilization on 24 nm-sized gold colloid

Stem-Cell Research - Genetic profiling of hair follicle stem cells yields treatment targets

Stem-Cell Research - Stem cells derived via nuclear transplantation regenerates infarcted heart

Stem-Cell Transplantation - IFN with very low-dose PBMC infusion induces complete remission in CML relapse

Tissue Engineering - Schwann cells implanted into acellular muscle provides graft for regeneration

Acute Coronary Syndromes - Company announces reinitiation of phase IIa trial in ACS

Acute Myeloid Leukemia - Ceplene trial in AML meets primary trial endpoint

Angiology - Platelet factor-4 and its derivatives control angiogenesis and invasion

Antimicrobials - New compounds antifungal and anticancer but inactive against HIV-1 and bacteria

Apoptosis - Cisplatin-induced apoptosis associated with mitochondrial dysregulation

Apoptosis - Cyclic AMP activation of ERK1/2 leads to transient inhibition of apoptosis

Bacteriology -  Campylobacter jejuni genes involved in GI tract colonization are identified

Bioengineering - Artificial cells will pave the way for new treatment modalities

Bioengineering - Genetically modified Sertoli cells survive allogeneic transplantation

Blood - Clinical trial to investigate treatment for CIDP

Blood - Phase III efficacy results announced for plasma treatment system

Blood Safety - A new rapid molecular assay detects at least four strains of the SEN virus

Blood Safety - Transfusion-transmitted bacterial infection risks reviewed

Blood Shortage - Life-threatening blood shortages projected for New York/New Jersey

Bone Marrow - FDA approves drug for bone marrow disease

Cardiovascular Disease - Nitrates should not be given along with any of the PDE5 inhibitors

Chronic Lymphocytic Leukemia - Activation-induced cytidine deaminase (AID) may be a marker for B-CLL

Complementary and Alternative Medicine -  Uncaria tomentosa extracts have potential application as immunomodulator

DNA Transcription - mTERF exists in mitochondria as active monomer and inactive large size complex

Diabetic Nephropathy - Use of cyclosporine in renal and pancreas transplantation reviewed

Diagnostics - Quantitative plasma CMV DNA assay very sensitive

Dialysis - Heparin coating of PVC tubing reduces DEHP exposure

Drug Development - MMC response cannot be predicted by NQOI or P450R protein expression

Drug Development - New factor Xa inhibitors synthesized

Endocrinology - ERalpha could play significant role in benign prostatic hyperplasia development

Endocrinology - Estrogen produces age-specific phenotypes in rat cholinergic basal forebrain

Enzymology - Proteolytic imbalance reversed after therapeutic surgery in breast cancer

Finance - BioArchive product line generates $2.2M in third quarter

Finance - Biotechnology company reports first quarter 2004 financial results

Finance - Blood-products company reports second consecutive profitable quarter

Finance - PolyHeme maker to raise $23.4 million

Gene Expression - Novel binding elements and gene targets for homeodomain protein BARX2 identified

Gene Inhibition - Silenced tazarotene-induced gene 1 negates retinoic acid responsiveness

Genomics -  Cryptosporidium parvum genome completely sequenced

Genomics - Genetic alterations within DR4 gene may be implicated in osteosarcoma formation

Genomics - Low-activity serotonin transporter genotype associated with heroin dependence

HIV/AIDS Immunology - Immune and endocrine change with group intervention in early stage HIV infection

HIV/AIDS Pharmacology - Pharmacological CDK inhibitors target virus and pathogenic mechanisms

HIV/AIDS Proteomics - HIV-1 nucleocapsid protein enhances annealing approximately fivefold

HIV/AIDS Research - Aldo-keto reductase family pathway generates HP1 from S-1360

HIV/AIDS Research - Autologous p2gag peptide blocks HIV-1 virion autolysis

HIV/AIDS Research - Crystal structures of HIV protease mutants reveal indinavir-binding site changes

HIV/AIDS Research - HIV-1 APIs modulate Ca2+ signaling in secretory epithelial cells

HIV/AIDS Research - Phlorotannins from brown alga E. cava inhibit HIV-1 RT and protease

HIV/AIDS Research - Prolonged HIV-1 culture increases its sensitivity to soluble CD4 neutralization

HIV/AIDS Research - Tenofovir regimens increase K65R selection to confer multiple NRTI resistance

HIV/AIDS Virology - HIV-1 viral load and infectivity reduced in presence of cellular prion protein

HIV/HCV Treatment - HCV therapy with IFN/RBV relatively safe in patients coinfected with HIV and HCV

Heart Surgery - Polymeric sealant suitable for anastomatic bleeding control

Helicobacter Pylori -  Helicobacter pylori infection high among dyspeptic patients in Ethiopia

Hepatitis B Virus - Diversity of hepatitis B virus in Dutch blood donors reported

Hepatitis B Virus - HBV DNA test should replace HBsAg and/or anti-HBc for blood donor screening

Herpesvirus - Simulect safe in pediatric renal transplant with low HHV-6 or EBV infection risk

Immunology - 5'-Methylthioadenosine modulates inflammatory response to hepatocyte endotoxin

Immunology - AOP-RANTES and heparinoids inhibit human macrophage activation

Immunology - Absence of NO production alone does not initiate endothelial cell activation

Immunology - Allicin holds promise for chronic inflammatory diseases

Immunology - Altered immune reaction linked to immunosuppressive potential of oral bactreria

Immunology - Beta-catenin signaling acts differently in prostatic or colorectal tumorigenesis

Immunology - Both macrophages and stromal cells clear apoptotic marrow-derived pre-B cells

Immunology - CyA C2 predicts total cholesterol in immunosuppressed kidney transplant patients

Immunology - Dendrites are chemoattracted to C3a after up-regulation of C3a receptor with IFN

Immunology - Distinct CXC chemokines show restricted expression in myeloid/nonmyeloid cells

Immunology - FTY720 may increase efficacy and tolerability of immunosuppressive regimens

Immunology - HIP-55 key novel component of synapse modulating T-cell activation

Immunology - Hyperfiltration not the rule following single kidney transplantation

Immunology - Medicinal fungus water extract promotes immunity and inhibits tumor metastasis

Immunology - Proinflammatory phenotype in niSMCs result in increased leukocyte recruitment

Immunology - TEPA study supports current phase I/II leukemia trial in the U.S.

Immunology - The mast cell directs the immune response

Immunology - sIg light chain restriction may not indicate mature B-cell phenotype in ALL

Immunosuppression - Cyclosporin and tacrolimus have equivalent results in lung transplantation

Immunosuppression - Cyclosporine remains the cornerstone of immunosuppression

Immunosuppression - Successful kidney transplants increase with cyclosporine experience

Infectious Disease - Transmission cycles of Pneumocystis jirovecii infections are linked

Inflammation - recHDLs reduce inflammation associated with ischemia/reperfusion and colitis

Ischemia - Stathmin marks cell proliferation in the recovery phase of renal failure

Kidney Disease - IgA nephropathy associated with X-linked thrombocytopenia

Legal Issues - Maryland hospital faces congressional review

Leukemia - MRI is an important tool in detecting recurrent acute lymphoblastic leukemia

Mergers and Acquisitions - Cell therapy company signs letter of intent to merge

Metabolic Pathway - Organelles are involved in tissue differentiation

Military Healthcare - Talent, Clinton push military health bill

Mutagenesis - Aberrant methylation of trail decoy receptor genes is common in many cancers

Neural Inflammation - Butyrate is anti-inflammatory in primary, brain-derived microglial cells

Neurology - MCP-1 involved in development of mechanical allodynia induced by nerve injury

Obstetrics - Iron supplements still leave pregnant women anemic in semirural Mexico

Opportunistic Infections - Prophylactic levofloxacin spawns drug-resistant microbes in cancer patients

Oral Surgery - Autologous fibrin-platelet glue improves maxillofacial surgery outcome

Osteoporosis - Calcium citrate decreases bone resorption markers more than calcium carbonate

Patents - Patents granted for blood volume analyzer kit in Canada, Japan

Pediatric Health - Engineer helps create world's first artificial heart for children

Pharmaceutical and Drug Development - Novel synthesis of protease inhibitors yield potent anti-HIV activity

Proteomics - Matrix gene and protein expressions change in radiation-exposed skin

SARS - Monitoring natural killer cells help differentiate SARS from M. Pneumoniae

Skin Cancer - Alpha-tocopherol may offer some protection against less aggressive melanomas

Stem Cells - New population of multilineage stem cells in umbilical cord blood isolated

Stem-Cell Research - 3-D analysis of cultured bone useful for continuous monitoring of tissue growth

Stem-Cell Research - Apoptosis requires participation of pro-apoptotic family member Bax

Stem-Cell Research - Different signaling pathways involved in pathogenesis of CML and EMS

Stem-Cell Research - Endodermal progenitors differentiate into hepatic and pancreatic lineages

Stem-Cell Research - Enhanced stem cell survival associated with specific APC mutations

Stem-Cell Research - Greater understanding of ocular stem-cell biology needed

Stem-Cell Research - Improved embryonic stem cell test predicts developmental toxicity

Stem-Cell Research - LIMK1/cofilin-mediated actin reorganization regulates stem cell migration

Stem-Cell Research - Many brainstem neurons express functional MOR or DOR receptors or both

Stem-Cell Research - Novel biomarkers of human pluripotent embryonic carcinoma stem cells identified

Stem-Cell Research - Novel method useful for cell-cell interaction studies and tissue engineering

Stem-Cell Research - Novel neuronal phenotypes generated from neural progenitor cells

Stem-Cell Research - Shock wave-promoted bone formation activates ERK and p38 kinase

Stem-Cell Research - Skin-originated stem cells isolated from pigs

Stem-Cell Research - Soluble Jagged-1 induces hematopoietic stem cell self-renewal

Stem-Cell Research - c-Kit and nestin expressing cells represent endocrine precursor cells

Stem-Cell Transplantation - Allogeneic stem cell transplant curative in amegakaryocytic thrombocytopenia

Stem-Cell Transplantation - Cell transplantation for Parkinson disease still in infancy

Stem-Cell Transplantation - Children recovering from stem-cell transplants suffer diminished resistance

Stem-Cell Transplantation - Pretreatment with hydroxyurea lowers rejection incidence in sickle cell disease

Thromboembolic Disorders - Anticoagulant for thromboembolic disorders effective in animal models

Tissue Engineering - Biodegradable support materials used to produce biphasic cartilage constructs

Tissue Engineering - Inkjet printing used for high-throughput cell patterning

Tissue Engineering - Preincubating tissue engineered constructs enhances donor cell retention

Transfusion Medicine - FACS assay suitable for HPA 1a screening

Transgenics - Pentraxin 3 helps control fungal recognition and phagocytosis

Transplant Medicine - Report: New approach has lung recipients taking far fewer drugs

Tumor Marker - Clinical marker CAF-1 distinguishes quiescent from proliferating cells

Tumor Suppression - PTEN is physically associated with platelet-derived growth factor

Tumorigenesis - Autocrine/paracrine SFRP 2 induces cellular resistance to apoptosis

West Nile - North Carolina health officials warn of West Nile threat

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