Stem-Cell Research
Enhanced stem cell survival associated with specific APC mutations
Published in Blood Weekly, June 10th, 2004
According to researchers at the University of Southern California, "Individuals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous polyposis (FAP) are born with normal appearing colons but later develop hundreds to thousands of polyps."
K.M. Kim and colleagues explained, "Tumor progression apparently starts after somatic loss of the normal APC allele, but germiline APC mutations may potentially alter niche stem cell survival through dominant-negative interactions or haploinsufficiency. Although morphologically occult, altered stem cell...
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Source: Blood Weekly (2004-06-10)
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