Stem-Cell Research
Genetic profiling of hair follicle stem cells yields treatment targets
Published in Blood Weekly, June 10th, 2004
According to recent research from the University of Pennsylvania, "The hair follicle bulge possesses putative epithelial stem cells. Characterization of these cells has been hampered by the inability to target bulge cells genetically. Here, we use a Keratin1-15 (Krt1-15, also known as K15) promoter to target mouse bulge cells with an inducible Cre recombinase construct or with the gene encoding enhanced green fluorescent protein (EGFP), which allow for lineage analysis and for isolation of the cells."
"We show that bulge cells in adult mice generate all epithelial cell types...
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Source: Blood Weekly (2004-06-10)
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