Gene Expression
Novel binding elements and gene targets for homeodomain protein BARX2 identified
Published in Blood Weekly, June 10th, 2004
"BARX2 is a homeobox transcription factor that influences cellular differentiation in various developmental contexts. To begin to identify the gene targets that mediate its effects, chromatin immunoprecipitation (ChIP) was used to isolate BARX2 binding sites from the human MCF7 breast cancer cell line," wrote researchers at Scripps Research Institute."
"Cloning and sequencing of BARX2-ChIP-derived DNA fragments identified 60 potential BARX2 target loci that were proximal to or within introns of genes involved in cytoskeletal organization, cell adhesion,...
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Source: Blood Weekly (2004-06-10)
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