Gene Inhibition
Silenced tazarotene-induced gene 1 negates retinoic acid responsiveness
Published in Blood Weekly, June 10th, 2004
According to a study from the United States, "a variety of tumor suppressor genes are down-regulated by hypermethylation during carcinogenesis. Using methylated CpG amplification-representation difference analysis, we identified a DNA fragment corresponding to the tazarotene-induced gene 1 (TIG1) promoter-associated CpG island as one of the genes hypermethylated in the leukemia cell line K562. Because TIG1 has been proposed to act as a tumor suppressor, we tested the hypothesis that cytosine methylation of the TIG1 promoter suppresses its expression and causes a loss of responsiveness to retinoic...
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Source: Blood Weekly (2004-06-10)
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