Immunology
AOP-RANTES and heparinoids inhibit human macrophage activation
Published in Blood Weekly, June 10th, 2004
"During transplantation, pancreatic islets release chemokines which promote macrophage attraction, hampering engraftment of islets. The aim of this study was to modulate chemotaxis and the immune response of human macrophages induced by islets," collaborators in Europe report.
"Human monocyte-derived macrophages of healthy subjects were exposed to supernatants of human islets," wrote S. Sigrist and coworkers. "Chemotaxis, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) release were evaluated. To modulate migration, human macrophages were incubated in the presence...
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Source: Blood Weekly (2004-06-10)
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