Published in Blood Weekly, June 17th, 2004
According to published research from Japan, "We reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor family, plays a key role in nitric oxide (NO)-mediated apoptosis of macrophages and pancreatic beta cells. We also showed that the cytosolic chaperone pair of hsp70 and dj1 (hsp40/hdj-1) or dj2 (HSDJ/hdj-2) prevents NO-mediated apoptosis upstream of cytochrome c release from mitochondria.
"To analyze roles of the chaperone pair in preventing apoptosis," reported T. Gotoh and colleagues, "RAW 264.7...
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