Apoptosis
CHOP-induced apoptosis mediated by Bax translocation from mitochondrial cytosol
Published in Blood Weekly, June 17th, 2004
According to published research from Japan, "We reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor family, plays a key role in nitric oxide (NO)-mediated apoptosis of macrophages and pancreatic beta cells. We also showed that the cytosolic chaperone pair of hsp70 and dj1 (hsp40/hdj-1) or dj2 (HSDJ/hdj-2) prevents NO-mediated apoptosis upstream of cytochrome c release from mitochondria.
"To analyze roles of the chaperone pair in preventing apoptosis," reported T. Gotoh and colleagues, "RAW 264.7...
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Source: Blood Weekly (2004-06-17)
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