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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . June 24th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Cardiovascular Disease - Metabolic syndrome positively associated with cardiovascular disease

Skin Cancer - More UVA than UVB fingerprint mutations in basal layer of human squamous tumors

Stem-Cell Research - Dopaminergic neurons generated from embryonic stem cells

Stem-Cell Research - Embryonic stem cells are an alternate marrow donor source

Tissue Engineering - Cartilage tissue regenerated by serum-free cultured chrondrocyte implantation

Allergy & Immunology - PAR-2-mediated activation enhances airway inflammation

Allergy Medicine - PAF responsiveness in subjects with plasma PAF acetylhydrolase deficiency

Allergy Medicine - Test methods evolving for newly emerging allergy epidemics

Anemia - Successful cord blood stem cell transplant reported

Antibacterial Research - NMR evidence found for independent domain structures in zoocin A

Antiphospholipid Syndrome - Endothelial microparticles may play role in thrombotic complications of APS

Apoptosis - Labeled Annexin A5 detects programmed cell death in vitro and in vivo

Assisted Reproduction - Medically assisted reproduction still risky in presence of chronic viral disease

Atherosclerosis - PAD patients should be aggressively treated for atherosclerotic risk factors

Bacteriology - Histopathologic changes in kidney and liver correlate with SPE B production

Biotechnology - Cytokine flow cytometry assesses cellular immune responses to viral antigens

Bleeding - Application submitted to FDA to market autologous thrombin processing device

Blood Banking - Autologous FG by CryoSeal FS System suggestive for hypothetical blood saving

Blood Screening - Consensus determines principles of screening and prevention of vCJD

Breast Cancer Survival and Mortality - CD105 identifies node-negative breast cancer patients with poor prognoses

Cancer Cell Biology - Perpetual cancer from leukemic stem cells described

Cancer Diagnosis - Immunomagnetic separation depicts esophageal cancer micrometastasis

Cancer Research - CEACAM6 crosslinking leads to increased extracellular matrix component adhesion

Cancer Therapy - Amifostine does not protect lungs from carmustine-containing chemotherapy

Cancer Treatment - Utah doctors determine 'good, bad' chemo

Cardiology - Cigarette smoking predicts reduced maximal FEV1 level in males but not females

Cardiology - Potential treatment for aortic aneurysm repair surgery given FDA fast track status

Cholesterol - Cholesterol regulates GCase activity/stability in Niemann-Pick disease type C

Chronic Lymphocytic Leukemia - Rituximab called most promising emerging drug for chronic lymphocytic leukemia

Chronic Myeloid Leukemia - A few questions remain concerning chronic myeloid leukemia

Collaborations - Option granted for rights to blood platelet modification technology

Complementary & Alternative Medicine - Licorice extract significantly improves learning and memory

Coronavirus - Previously undescribed coronavirus associated with respiratory disease in humans

Crosslinking - RPA binds primer-template junction in absence of its major ssDNA-binding domains

Cytomegalovirus - Inverse correlation between CD27 quantitation and cytotoxic effector function

Detection - RAPD analysis useful for genotyping clinical Candida spp. isolates

Diagnostics - Automated schistocyte counting method evaluated

Diagnostics - Flow cytometry is utilized to study natural killer T cells

Drug Advertising - FDA warning letter issued on promotional materials for Advate

Drug Development - Chitosan microspheres potential carrier for drugs

Drug Resistance - Topoisomerase II alpha foils the effectiveness of etoposide in myeloma cells

Finance - $3M private placement to fund Oxycyte blood substitute clinical trials

Gastroenterology - Promising therapies available for the treatment of Crohn disease

Gene Transfer - 2-Amine is major bystander metabolite when CB 1954 is activated by NTR in tumors

Genetic Engineering - Stem cell factor gene-modified natural killer cells overwhelm tumor cells

Genomics - Gene encoding C. stercorarium beta-xylosidase Xyl43B in E. coli sequenced

Genomics - p16(INK4a) and p53 tumor suppressor genes altered in hTERT-immortalized cells

Gynecology - Polycystic ovary follicular excess may be main culprit for follicular arrest

HIV Diagnosis - HIV-1/2 oral fluid rapid tests under development

HIV/AIDS - AIDS-related NHL is treated traditionally as supportive care improves

HIV/AIDS - Argininamide binding arrests global motions in HIV-1 TAR RNA

HIV/AIDS - Ezrin/CD95 linkage key role regulating susceptibility to CD95-mediated apoptosis

HIV/AIDS - Intracellularly expressed HIV-1 Tat protein inhibits neural cell proliferation

HIV/AIDS Gene Therapy - TAT-pK/DNA complex useful way to package therapeutic genes for cell transduction

HIV/AIDS Progression - Timed ablation of regulatory CD4+ T cells prevents AIDS progression

HIV/AIDS Research - Central domain of HIV-1 matrix protein influences virus infectivity

HIV/AIDS Research - Channels formed by Vpu result from the self-assembly of monomers

HIV/AIDS Research - FIV env-mediated fusion mechanism and kinetics are similar to HIV env

HIV/AIDS Research - Overexpression of Oct-1 or -2 has no effect on HIV-1 transcription in CD4 cells

HIV/AIDS Treatment - Cell surface targets identified for HIV-1 therapeutics using genetic screens

Health Risk - Boy dies of blood infection; friends, relatives treated

Health and Fitness - Multiple myeloma patients commit to exercise based on a number of factors

Heart Failure - Anemia adversely affects outcome of diastolic heart failure patients

Hematology - Age and packed cell transfusion volume act synergistically to increase mortality

Hematology - Bfl-1/A1 is a potent antiapoptotic stimulant in myeloma cells

Hematology - Cryoprecipitate-removed plasma is factor IX source for treatment of hemophilia B

Hematology - Updated results presented from phase III study of Dacogen in MDS

Hemophilia A - Linkage analysis and antigen assay detects 50% of carriers

Hepatitis C - Oral prodrug selected for front-line treatment of chronic hepatitis C

Hepatitis C Virus - Combinations of Ig GM and KM phenotypes associated with outcome of HCV infection

Herpesvirus - HHV-8 vFLIP essential for survival of infected lymphoma cells

Immunology - Angiotensin II receptors modulate murine macrophage activity and phagocytosis

Immunology - Anti-Gal IgG potentiates NK cell migration via endothelial cell activation

Immunology - Neuropeptides do not induce mediator release in isolated intestinal mast cells

Immunology - Novel polymorphism in cytoplasmic region of IgA Fc receptor gene found

Immunology - Protection against infection may depend upon healthy host-microbe interactions

Immunology - Reduced B cell CD22 expression does not effect S. aureus arthritis and sepsis

Immunology - S1P receptor activation by FcepsilonRI trigger required for mast cell function

Immunology - Selected peptides functionally represent the Fc-gammaRII-binding part of IgG1

Infectious Disease - Modes of hantavirus transmission inferred from mitochondrial DNA analyses

Leukemia - Elderly patients benefit from intensive treatment

Leukemia - U.S. research hospital helps Brazilian children fight leukemia

Liver Disease - Nonalcoholic fatty liver disease encompass benign steatosis and steatohepatitis

Liver Failure - Treatment options vary for acute liver failure

Lymphoma - Initial bone marrow involvement is infrequent in nasal-type NK/T cell lymphoma

Measles Outbreaks - Measles outbreak control in adult populations discussed

Molecular Diagnostics - Molecular typing techniques are useful for detecting pathogenic fungi

Myelodysplastic Syndromes - FDA approves Vidaza (azacitidine for injectable suspension) for MDS

Neuroblastoma - Salvage therapy influences survival in children with recurrent neuroblastoma

Neuroscience - Alterations in tau transcripts correlate with sporadic tauopathy neurofilament

Neuroscience - proNGF exhibits neurotrophic activity but is less active than mature NGF

Non-Hodgkin Lymphoma - Extranodal non-Hodgkin lymphoma can occur in the sinonasal tract

Non-Hodgkin Lymphoma - Pesticide exposure is not related to increased risk of NHL in southern Sweden

Obstetrics - Factor V Leiden associated with increased risk of obstetric complications

Oncogenesis - Many genes synergize with Cbfb-MYH11 to produce acute myeloid leukemia

Oncology - Thalidomide treats multiple myeloma by targeting bone marrow angiogenesis

Phenotyping - EBV-transformed B-cell lines used for reference and research in routine lab

Protozoal Infection - CTLA-4 blockage increases resistance to infection with Trypanosoma cruzi

Recurrent Spontaneous Abortion - Elevated maternal plasma levels of factor VIII linked to increased RSA risk

Retrovirus - FIV replication in activated CD4+CD25+T cells independent of cell proliferation

Stem Cells - Preclinical studies show that stem cells may reverse diabetes in mice

Stem-Cell Research - Activated neural stem cells contribute to stroke-induced neurogenesis

Stem-Cell Research - Allogeneic PBSCT is feasible for children with beta/beta and beta/E

Stem-Cell Research - BMP-2 controls key early commitment step in embryonic stem cell differentiation

Stem-Cell Research - Cord blood stem cells plus fibrin platelet glue used for wound repair

Stem-Cell Research - Developing neonatal rabbit appendix is seeded by immature blood-borne B cells

Stem-Cell Research - GAMT deficiency causes biochemical adaptations in brain and skeletal muscle

Stem-Cell Research - Large defect bone reconstruction using BM-derived SSC not proven for non-union

Stem-Cell Research - Mesenchymal stem cells from adult mouse bone marrow isolated and characterized

Stem-Cell Research - Novel DZIP gene expressed in embryonic stem cells and germ cells is identified

Stem-Cell Research - Nucleosome remodeling defect prevents IL-12(P35) transcription in neonatal DC

Stem-Cell Research - Pluripotent stem cell line expressing the AML1-ETO fusion protein established

Stem-Cell Research - Poly(NiPA-co-AAc) gel may provide optimal chondrocyte propagation 3D environment

Stem-Cell Research - Regenerative response in ischemic brain is restricted by p21(Cip1/waf1)

Stem-Cell Research - Side population cells in human/mouse epidermis lack stem cell characteristics

Stem-Cell Research - Skeletal muscle differentiation potential of adult BM cells may lead to therapy

Stem-Cell Transplantation - Allogeneic hematopoietic stem cell transplant for lymphoma should be selective

Stem-Cell Transplantation - Predictors of outcome identified in patients with metastatic rhabdomyosarcoma

Tissue Engineering - Endocytosis of nano-environment produced by colloidal lithography by fibroblasts

Tissue Engineering - Nanocolumns produced for cell culture using colloidal lithography

Tissue Engineering - Web-like structured novel sheet promising for custom-shaped bone regeneration

Transfusion Medicine - GB virus C/hepatitis G virus infections are rare and self-limiting in India

Ultrasonography - Ultrasound affects structure and function of proteins of PPSB complex

Viral Disease - Biotech company testing possible antidote for bioterrorism viruses

Virology - Dendritic cell-associated function impairment distinguish HCV and HIV infection

Virology - Human Coronavirus 229E in nasal specimens detected by RT-PCR hybridization assay

West Nile Virus - West Nile virus-associated encephalitis seen in immunocompromised patients

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