Hemophilia A

Linkage analysis and antigen assay detects 50% of carriers

Published in Blood Weekly, June 24th, 2004

Linkage analysis and factor VIIIC (FVIIIC)-von Willebrand factor (vWF) antigen assay detected 50% of hemophilia A carriers among 52 women from 30 families with hemophilic patients.

R.P.H. Ahmed and colleagues at the All India Institute of Medical Science in New Delhi reported "[t]he allelic frequency for the marker Bcl 1 and Xba 1 was 0.58 and 0.54, respectively, for the positive alleles and 0.42 and 0.46, respectively, for the negative alleles. The heterozygosity frequency of Bcl 1 and Xba 1 was 0.65 and 0.55, respectively.

"Of the 52 females, 30 were mothers of hemophilic patients and 22 were sisters of hemophilic patients. Of the 30 mothers,...

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Source: Blood Weekly (2004-06-24)

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